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While calcium from food sources is recommended as part of a healthy diet, researchers say a genetic predisposition to higher calcium levels is a possible factor for CAD and heart attack. The study’s lead author Dr Colon  J. Larsson and hisHigh levels of calcium in the bloodstream increase your risk of coronary artery disease and heart attack, according to new research out of DenMark. Genetic predisposition to higher serum calcium levels is potentially causally related to higher risk of coronary artery disease (CAD) and myocardial infarction (MI), a mendelian randomization study reported in the Journal of the American Medical Association.

Genome-wide association studies have implicated a common genetic variant in chromosome 6p24 in coronary artery disease, as well as four other vascular diseases: migraine headache, cervical artery dissection, fibromuscular dysplasia, and hypertension. However, it has not been clear how this polymorphism affects the risk for so many diseases. In the journal Cell on July 27, researchers show how this DNA variant enhances the activity of a gene called endothelin-1 (EDN1), which is known to promote vasoconstriction and hardening of the arteries.The finding from this study corroborates results from several observational studies showing a positive association of serum calcium levels with risk of cardiovascular disease,” the researchers wrote. But, they cautioned,

“Whether the risk of CAD associated with lifelong genetic exposure to increased serum calcium levels can be translated to a risk associated with short-term to medium-term calcium supplementation is unknown.”  Simple identification methods can protect information in a database from attackers, a new study suggests.Genetic ancestry testing led one woman to learn that her father and another baby boy had been switched at birth, the Washington Post reports.

 

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